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PubMed · 8602406

Persistence: a new statistic for characterizing ion-channel activity.

D R Fredkin·J A Rice·D Colquhoun·A J Gibb
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Abstract

We introduce and illustrate by examples a new statistical technique, the persistence function, for characterizing ion-channel activity in a single-channel patch-clamp recording. Persistence is a function of both current and time. It is the probability that the current is at a given level (conditional on it having been at that level at an earlier time). Viewed as a function of current it exhibits the prominent conductance levels present in the recording, and viewed as a function of time for a conductance level it portrays the kinetics at that level.

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Ion ChannelsKineticsModels, BiologicalPatch-Clamp TechniquesReceptors, N-Methyl-D-AspartateStatistics as TopicJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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BibTeXRIS

D R Fredkin, J A Rice, D Colquhoun, A J Gibb. 1995-12-29. Persistence: a new statistic for characterizing ion-channel activity.. https://doi.org/10.1098/rstb.1995.0170

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