PubMed · 860608
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J D Joubert. 1977. [Is the Rolls-Royce solution in the operating rooms a solution?].. https://pubmed.ncbi.nlm.nih.gov/860608/
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The objectives of the present work were to investigate techniques for the continuous, qualitative monitoring of VOCs and to see how VOC levels were influenced by normal household activities. Three different methods were investigated to measure the VOC levels: infrared spectroscopy, photoionization detection, and gas chromatographic analysis of absorbent tube samples. Results were presented that related changes in levels of VOCs to various human activities commonly occurring in residences, and data were presented that indicated activities such as cooking, arts and crafts, cleaning floors, and painting contributed to short-term increases in VOC levels. VOC levels were diminished by turning on the air conditioner. Results on the effect of humidity on VOCs, both in homes and controlled chambers, were reported.
We have investigated the effectiveness of house dust-mite (HDM) allergen avoidance through clean room (CR) therapy in patients with atopic dermatitis (AD) having high HDM-specific IgE RAST levels. All patients (N = 30) demonstrated marked improvement in symptom, a long-term remission (mean, 8.4 months), and significant decreases in eosinophil count (p less than 0.01), basophil count (p less than 0.05), serum lactate dehydrogenase activity (p less than 0.01), and HDM-specific IgG levels (p less than 0.05). By contrast, the patients with AD (N = 11), who scored 0 on HDM allergen-specific IgE RAST score underwent "CR" therapy, and the patients with AD (N = 10) having high HDM-specific IgE RAST levels were hospitalized in a common sickroom (nonclean room). All the patients (N = 21) exhibited slight improvement in symptoms and a significant decrease in serum lactate dehydrogenase activity. The period of recurrence after the therapy was brief. The results of measurement of airborne house-dust particles indicated that our "CR" fell within class 10,000. Therefore, it is very likely that the mechanism at work in the CR therapeutic approach is its ability to eliminate fecal pellets of the HDM.
Control of the environment is a cost-effective method of limiting allergic reactions in susceptible people. For physicians working with allergic patients, this approach involves guiding the patient and family in ridding their home and surroundings of allergens and irritants. Dr. Klein discusses the environmental-control protocol, particularly in regard to dust mites, mold, pollen, and pets.