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PubMed · 8606678

Ibutilide.

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Abstract

Ibutilide fumarate (Corvert -- Pharmacia & Upjohn), a new antiarrhythmic drug for intravenous use, has been approved by the US Food and Drug Administration for acute termination of atrial fibrillation or flutter of recent onset.

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Anti-Arrhythmia AgentsClinical Trials as TopicHumansSulfonamidesJournal Article

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1996-04-12. Ibutilide.. https://pubmed.ncbi.nlm.nih.gov/8606678/

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Ibutilide: a class III rapidly acting antidysrhythmic for atrial fibrillation or atrial flutter.

Ibutilide is an intravenous Class III antidysrhythmic approved for the treatment of recent onset atrial fibrillation or atrial flutter. Pharmacological effect occurs within 30 min, and the efficacy approaches 40%. In contrast to DC electrical cardioversion, which requires anesthesia, pharmacologic cardioversion offers an alternative in which sedation can be avoided. Patients receiving ibutilide should be monitored for at least 4 h after completed drug administration because of a small chance of ventricular dysrhythmia, mainly torsades de pointes. Careful patient selection is the key to avoiding dysrhythmic complications. The purpose of this article is to review the mechanisms, clinical applications, potential complications, and appropriate use of ibutilide.

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