Nitric oxide and superoxide anion production decrease with age in resident and activated rat peritoneal macrophages.

E Alvarez; A Machado; F Sobrino; C Santa Maria

doi:10.1006/cimm.1996.0103

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Nitric oxide and superoxide anion production decrease with age in resident and activated rat peritoneal macrophages.

E Alvarez·A Machado·F Sobrino·C Santa Maria

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Abstract

Superoxide anion and nitric oxide production have been studied in resident and activated peritoneal macrophages of 3-, 12-, and 24-month-old rats. Some key enzymes involved in the metabolism of glucose were also studied in relation to aging. Production of O2 and NO was reduced in all cases in middle-aged (12 months) and old (24 months) animals. Malic enzyme and citrate synthase activity shows a progressive reduction with age. Hexoquinase, pyruvate quinase, and lactate dehydrogenase activities decrease sharply from 3 to 12 months with no significant change between 12 and 24 months. Taken as a whole, the results of enzyme activity suggest that aging may reduce the capacity for glucose utilization in macrophages.

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Aging Animals Cells, Cultured Macrophage Activation Macrophages, Peritoneal Nitric Oxide Rats Superoxides Journal Article Research Support, Non-U.S. Gov't

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E Alvarez, A Machado, F Sobrino, C Santa Maria. 1996-04-10. Nitric oxide and superoxide anion production decrease with age in resident and activated rat peritoneal macrophages.. https://doi.org/10.1006/cimm.1996.0103

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