HLA and chronic active hepatitis (CAH).

L J Dumble; I R Mackay

doi:10.1159/000198010

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HLA and chronic active hepatitis (CAH).

L J Dumble·I R Mackay

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Abstract

A family study of 2 parents and 5 SD identical (HLA-A1, A3, B7, B8) siblings, one of whom has 'classic CAH' has been used to demonstrate that in this family the maternally ingerited HLA-B8 antigen is not solely serving to mark genetic predisposition to this disease. The patient's lymphocytes both responded to, and stimulated those of her 4 siblings in MLR indicating the possible involvement of an HLA-D antigen in CAH. This HLA-D antigen could have been of paternal orgin, or could have been a result of a recombination event involving an HLA-D antigen liked to the maternal HLA-A2, B12 haplotype. The lymphocytes of the four helthy siblings were mutually unresponsive in MLR.

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Chronic Disease Female HLA Antigens Hepatitis Hepatitis, Viral, Human Histocompatibility Antigens Homozygote Humans Lymphocytes Male Phenotype Journal Article

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L J Dumble, I R Mackay. 1977. HLA and chronic active hepatitis (CAH).. https://doi.org/10.1159/000198010

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