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Dose-response relationship between urinary cadmium concentration and beta2-microglobulinuria using logistic regression analysis.

M Hayano·K Nogawa·T Kido·E Kobayashi·R Honda·I Turitani
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Abstract

Logistic regression analysis was used to investigate the dose-response relationship for environmental cadmium exposure and to consider the effect age had on this association. The target population comprised 3178 inhabitants of Japan who were more than 50 y of age and who lived in a cadmium-polluted area and 1134 inhabitants who lived in nonpolluted areas of Japan. Logistic regression analysis was completed on the dose-response relationship between urinary cadmium concentration (i.e., an indicator of cadmium body burden) and beta2-microglobulinuria (i.e., an index of renal tubular dysfunction caused by exposure to cadmium). Both age and urinary cadmium concentration were associated significantly with beta2-microglobulinuria. Based on the relationship that was determined, we calculated, by age and sex, the values of urinary cadmium concentration that corresponded to the prevalence rates of beta2-microglobulinuria in the nonpolluted population. The resulting values were 1.6-3.0 micrograms/g creatinine for men and 2.3-4.6 micrograms/g creatinine for women.

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Age FactorsAgedAged, 80 and overCadmiumDose-Response Relationship, DrugEnvironmental ExposureFemaleHumansJapanLogistic ModelsMaleMiddle AgedPrevalenceSex FactorsSpectrophotometry, Atomicbeta 2-MicroglobulinComparative StudyJournal Article

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M Hayano, K Nogawa, T Kido, E Kobayashi, R Honda, I Turitani. Dose-response relationship between urinary cadmium concentration and beta2-microglobulinuria using logistic regression analysis.. https://doi.org/10.1080/00039896.1996.9936011

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