Hepatitis C virus infection.

Abstract

Hepatitis C, previously termed parenterally transmitted NANB hepatitis, is caused by a single-stranded RNA virus (HCV). Infection with this virus has epidemiologic characteristics similar to hepatitis B, with infection from contaminated blood appearing to be a primary source of disease. Although 80% to 90% of the viral hepatitis associated with blood transfusions used to be the most common mechanism for HCV transmission, parenteral drug abuse has become the major documented risk factor in the United States. Health care workers face occupational hazards for HCV infection primarily through needlestick and other contaminated sharps accidents, although the risks are much lower than those historically documented for HBV. Current universal bloodborne precautions for infection control appear to be effective against occupational cross-infection in patient care settings. Ongoing studies in patients with long-term persistent hepatitis C are investigating the usefulness of prolonged interferon therapy to reduce hepatic damage and HCV chronicity.