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Circulating intercellular adhesion molecule 1 predicts non-specific elevation of alpha 1-fetoprotein.

E Falleti·C Fabris·M Pirisi·G Soardo·D Vitulli·P Toniutto·E Bartoli·N Bortolotti·F Gonano
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Abstract

Molecules governing cellular interactions have been suggested to be involved in the spurious elevation of alpha 1-fetoprotein (AFP) in non-neoplastic liver disease. To explore this controversial issue, we measured AFP, circulating intercellular adhesion molecule 1 (cICAM-1), and common liver function tests in 111 patients (71 male, 40 female). Eighty-four patients had non-neoplastic chronic liver disease and 27 had hepatocellular carcinoma. The concentration of cICAM-1 was determined immunoenzymatically. In patients with non-neoplastic chronic liver disease, univariate analysis demonstrated a significant correlation between AFP and cholinesterase (R = -0.397, P < 0.001), aspartate aminotransferase (R = 0.421, P < 0.001), bilirubin (R = 0.231, P < 0.05) and cICAM-1 (R = 0.430, P < 0.001). Multivariate analysis among these variables and AFP indicated cICAM-1 to be the strongest independent predictor of AFP. We conclude that cICAM-1 compares favourably with liver function tests in predicting non-specific AFP variations in non-neoplastic chronic liver disease, suggesting a link between targeting of the inflammatory damage to the hepatocyte and development of neoplasia.

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AdultAgedAged, 80 and overCarcinoma, HepatocellularFemaleHumansIntercellular Adhesion Molecule-1Liver DiseasesLiver NeoplasmsMaleMiddle AgedPredictive Value of Testsalpha-FetoproteinsJournal Article

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BibTeXRIS

E Falleti, C Fabris, M Pirisi, G Soardo, D Vitulli, P Toniutto, E Bartoli, N Bortolotti, F Gonano. 1996. Circulating intercellular adhesion molecule 1 predicts non-specific elevation of alpha 1-fetoprotein.. https://doi.org/10.1007/bf01220805

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