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PubMed · 8645450

Engineering challenges in cell-encapsulation technology.

C K Cotton
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Abstract

The use of implantable immunoisolation devices, in which the tissue is protected from immune rejection by enclosure within a semipermeable membrane or encapsulant, is one approach in the development of cell therapies. However, further research is required in the areas of: tissue supply from primary or cell-culture sources; maintenance of cell viability and function, its relationship to device design, and the role of, and factors affecting, oxygen-supply limitations; and, protection from immune rejection, especially in view of the mechanisms thought to operate in the presence of a semipermeable membrane, the properties of that membrane, and the implications for biology and device design.

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BiotechnologyCapsulesCell TransplantationCellsHumansMembranes, ArtificialTissue PreservationJournal ArticleReview

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C K Cotton. 1996. Engineering challenges in cell-encapsulation technology.. https://doi.org/10.1016/0167-7799(96)10021-4

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