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PubMed · 8650582

Aberrant B cell development and immune response in mice with a compromised BCR complex.

R M Torres·H Flaswinkel·M Reth·K Rajewsky
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Abstract

The immunoglobulin alpha (Ig-alpha)-Ig-beta heterodimer is the signaling component of the antigen receptor complex on B cells (BCR) and B cell progenitors (pre-BCR). A mouse mutant that lacks most of the Ig-alpha cytoplasmic tail exhibits only a small impairment in early B cell development but a severe block in the generation of the peripheral B cell pool, revealing a checkpoint in B cell maturation that ensures the expression of a functional BCR on mature B cells. B cells that do develop demonstrate a differential dependence on Ig-alpha signaling in antibody responses such that a signaling-competent Ig-alpha appears to be critical for the response to T-independent, but not T-dependent, antigens.

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AnimalsAntibody FormationAntigensAntigens, CDAntigens, T-IndependentB-LymphocytesBone Marrow CellsCD79 AntigensCell LineageGene Rearrangement, B-LymphocyteGene TargetingGenes, ImmunoglobulinHematopoietic Stem CellsLymphoid TissueMiceMice, Inbred C57BLReceptors, Antigen, B-CellSignal TransductionJournal ArticleResearch Support, Non-U.S. Gov't

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R M Torres, H Flaswinkel, M Reth, K Rajewsky. 1996-06-21. Aberrant B cell development and immune response in mice with a compromised BCR complex.. https://doi.org/10.1126/science.272.5269.1804

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