Recombination-dependent mutation in non-dividing cells.

S M Rosenberg; R S Harris; S Longerich; A M Galloway

doi:10.1016/0027-5107(95)00092-5

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PubMed · 8657199

Recombination-dependent mutation in non-dividing cells.

S M Rosenberg·R S Harris·S Longerich·A M Galloway

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Abstract

Over the past 6 years an unexpected way of making mutations in bacteria has challenged concepts of the genetic mechanisms behind evolution. Mechanistic studies of these so called 'adaptive' mutations are revealing a novel molecular mechanism involving DNA double-strand breaks, genetic recombination, probable DNA polymerase errors, and the possible suspension of mismatch repair during the reversion of a lac frameshift mutation in Escherichia coli. The molecular details of this process are altering our understanding of how mutations form in non-dividing cells.

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Adaptation, Physiological Cell Division DNA Damage DNA Repair DNA Replication DNA-Directed DNA Polymerase Escherichia coli Frameshift Mutation Lac Operon Methylation Models, Genetic Mutagenesis Recombination, Genetic Journal Article Research Support, Non-U.S. Gov't

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S M Rosenberg, R S Harris, S Longerich, A M Galloway. 1996-02-19. Recombination-dependent mutation in non-dividing cells.. https://doi.org/10.1016/0027-5107(95)00092-5

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