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Prefrontal cortex and working memory for spatial response, spatial location, and visual object information in the rat.

R P Kesner·M E Hunt·J M Williams·J M Long
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Abstract

In the first experiment, rats were trained on a working memory task for a spatial response (right-left turn) information using a delayed matching-to-sample procedure. Following lesions of the medial prefrontal cortex (MPF), which includes anterior cingulate and medial precentral cortex, there was a profound working memory deficit even at the shortest delay. In the second experiment, rats were trained on a working memory task for spatial location information using a delayed matching-to-sample procedure. Following lesions of the MPF, there was only a mild working memory deficit, whereas following dorsal hippocampal lesions there was a profound working memory deficit even at the shortest delay. In the third experiment, rats were trained on a working memory task for visual object information using a delayed nonmatching-to-sample procedure. Following lesions of the MPF, there were no working memory deficits, whereas following lesions of the prelimbic and infralimbic cortex there was a profound working memory deficit even at the shortest delay. The results suggest that different neural subregions of the prefrontal cortex mediate working memory for specific attribute information.

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AnimalsBehavior, AnimalHippocampusMaleMemoryPrefrontal CortexRatsReaction TimeVisual PathwaysJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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R P Kesner, M E Hunt, J M Williams, J M Long. Prefrontal cortex and working memory for spatial response, spatial location, and visual object information in the rat.. https://doi.org/10.1093/cercor%2F6.2.311

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