Protein import into the nucleus.

G Schlenstedt

doi:10.1016/0014-5793(96)00583-2

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Protein import into the nucleus.

G Schlenstedt

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Abstract

The transport of proteins from the cytoplasm into the nucleus is a multistep process. The nuclear localization sequence (NLS) of a transport substrate associates with the heterodimeric NLS-receptor which binds to a subset of proteins of the nuclear pore complex (NPC). Translocation through the NPC is energy-dependent and requires the small GTPase Ran. Proteins that interact with Ran in either the GDP-bound or the GTP-bound state coordinate transfer through the NPC. Lastly, the NLS-receptor/ substrate complex and Ran reach the nuclear side of the NPC where the complex disassembles.

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Amino Acid Sequence Animals Biological Transport Carrier Proteins Cell Nucleus Humans Molecular Sequence Data Nuclear Envelope Nuclear Proteins Nucleocytoplasmic Transport Proteins Protein Sorting Signals Proteins Receptors, Cell Surface Saccharomyces cerevisiae Proteins Xenopus Proteins ran GTP-Binding Protein Journal Article Review

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G Schlenstedt. 1996-06-24. Protein import into the nucleus.. https://doi.org/10.1016/0014-5793(96)00583-2

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