Adaptive estimation of latency changes in evoked potentials.

X Kong; N V Thakor

doi:10.1109/10.481988

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PubMed · 8682530

Adaptive estimation of latency changes in evoked potentials.

X Kong·N V Thakor

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Abstract

Changes in latency of evoked potentials (EP) may indicate clinically and diagnostically important changes in the status of the nervous system. A low signal-to-noise ratio of the EP signal makes it difficult to estimate small, transient, time-varying changes in latency, or delays. Here, we present an adaptive algorithm that estimates small delay (latency change) values even when EP signal amplitudes are time-varying. When the delay is time invariant, the adaptive algorithm produces an unbiased estimate with delay estimation error less than half of the sampling interval. A lower estimation error variance is obtained when, in a pair of signals, the adaptive algorithm delays the signal with the higher SNR. The adaptive algorithm delays the signal with the higher SNR. The adaptive delay estimation algorithm was tested on intra-operative recordings of somatosensory EP, and analysis of those recordings reveals that the anesthetic etomidate produces a step change in the amplitude and latency of the EP signals.

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Algorithms Anesthetics, Intravenous Artifacts Brain Computer Simulation Electroencephalography Etomidate Evoked Potentials Evoked Potentials, Somatosensory Humans Models, Neurological Reaction Time Signal Processing, Computer-Assisted Time Factors Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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X Kong, N V Thakor. 1996. Adaptive estimation of latency changes in evoked potentials.. https://doi.org/10.1109/10.481988

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