Randomised comparison between a loading and incremental dose model for ritodrine administration in preterm labour.

C A Holleboom; J M Merkus; L W van Elferen; M J Keirse

doi:10.1111/j.1471-0528.1996.tb09840.x

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PubMed · 8688398

Randomised comparison between a loading and incremental dose model for ritodrine administration in preterm labour.

C A Holleboom·J M Merkus·L W van Elferen·M J Keirse

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Abstract

OBJECTIVE: To compare a new loading dose regimen for intravenous ritodrine administration in preterm labour with the conventional dose regimen. DESIGN: Multicentre randomised trial using numbered opaque sealed envelopes. SETTING: Five teaching hospitals in the Netherlands. PARTICIPANTS: Women (n = 203) in preterm labour at less than 34 weeks of gestation. INTERVENTIONS: Women received either a loading dose ritodrine infusion followed, as soon as tocolysis was reached, by a decrease in infusion rate or the conventional schedule of increasing doses until uterine quiescence was achieved. RESULTS: Frequency of successful tocolysis (71%) and duration of treatment (55 h) were similar in both groups, but the loading dose schedule was better tolerated with fewer adverse events. Also the number of dose adjustments was smaller than in the incremental dose group (P < 0.001). Overall, the differences between the two regimens were unexpectedly small. CONCLUSIONS: Despite the small differences, the loading model is easier to apply, requires fewer dose adjustments, is better tolerated with less side effects, and reduces the likelihood of clinical error.

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Dose-Response Relationship, Drug Double-Blind Method Female Heart Rate Heart Rate, Fetal Humans Infusion Pumps Infusions, Intravenous Obstetric Labor, Premature Pregnancy Ritodrine Tocolytic Agents Treatment Outcome Clinical Trial Comparative Study Journal Article Multicenter Study Randomized Controlled Trial

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C A Holleboom, J M Merkus, L W van Elferen, M J Keirse. 1996. Randomised comparison between a loading and incremental dose model for ritodrine administration in preterm labour.. https://doi.org/10.1111/j.1471-0528.1996.tb09840.x

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