Platelet aggregation is inhibited by phycolectins.

K Matsubara; H Sumi; K Hori

doi:10.1007/bf01969724

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Platelet aggregation is inhibited by phycolectins.

K Matsubara·H Sumi·K Hori

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Abstract

Lectins from four marine algal species were examined for interaction with human platelets. The lectin designated hypnin A, from the red alga Hypnea japonica, inhibited adenosine diphosphate (ADP)- or collagen-induced human platelet aggregation in a dose-dependent manner. Complete inhibition was observed at concentrations of 100 and 5 micrograms/ml of the lectin with ADP (2 microM) and collagen (0.2 microgram/ml)-induced platelet aggregation, respectively. At the inhibitory concentration of 0.5 to 100 micrograms/ml, the lectin did not induce aggregation of resting platelets. Lectins from the other three algal species also inhibited ADP-induced human platelet aggregation. These results indicate that the algal lectins are a new group of inhibitors and may be useful to study glycoconjugates on platelet membranes and to design novel platelet aggregation inhibitors.

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Adenosine Diphosphate Amino Acid Sequence Collagen Dose-Response Relationship, Drug Fibrinogen Hemagglutinins Humans Lectins Molecular Sequence Data Platelet Aggregation Platelet Aggregation Inhibitors Platelet Glycoprotein GPIIb-IIIa Complex Rhodophyta Journal Article

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K Matsubara, H Sumi, K Hori. 1996-06-15. Platelet aggregation is inhibited by phycolectins.. https://doi.org/10.1007/bf01969724

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