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PubMed · 870073

Iron removal from transferrin. An experimental study.

S Pollack·G Vanderhoff·F Lasky
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Abstract

We have studied the facilitation of iron transfer from transferrin to desferrioxamine by various anions. Most of the anions which can substitute for HCO-3 in the ternary complex of transferrin - Fe - HCO3 do not facilitate iron transfer; anions which do facilitate iron transfer do not necessarily form stable ternary complexes. Combinations of anions effective in transfer have a less-than-additive effect, suggesting a common reaction pathway. We suggest that the transfer of iron from transferrin to desferrioxamine involves a substitution step and a subsequent chelation step, and that the efficiency of the overall reaction is a function of both these attributes of the anion.

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DeferoxamineHumansIronKineticsTransferrinJournal Article

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BibTeXRIS

S Pollack, G Vanderhoff, F Lasky. 1977-04-27. Iron removal from transferrin. An experimental study.. https://doi.org/10.1016/0304-4165(77)90205-7

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