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PubMed · 870116

[Decrease in the tissue-specific resistance of gastric epithelium to acute cell death following inhibition of DNA synthesis].

O S Frankfurt
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Abstract

Administration to mice of hydroxyurea caused an acute death of an insignificant number of DNA-synthesizing cells in the epithelium of the glandular stomach. When actinomycin D was injected 8 hours prior to hydroxyurea there occurred a sharp intensification of cell degeneration: about 80% of the cells which synthesized DNA during the hydroxyurea administration proved to degenerate. No intensifying action was produced when actinomycin D was injected simultaneously with hydroxyruea. It is supposed that actinomycin D intensified the protein synthesis in the cells of the stomach (the "superinduction" effect), this increasing their sensitivity to the inhibition of the DNA synthesis.

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AnimalsCell SurvivalDNADactinomycinDrug InteractionsEpitheliumGastric MucosaHydroxyureaMiceOrgan SpecificityEnglish AbstractJournal Article

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O S Frankfurt. 1977. [Decrease in the tissue-specific resistance of gastric epithelium to acute cell death following inhibition of DNA synthesis].. https://pubmed.ncbi.nlm.nih.gov/870116/

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