[Sympathetic nervous system and endothelial function in heart failure].

C Binggeli; R R Wenzel; G Noll

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PubMed · 8701190

[Sympathetic nervous system and endothelial function in heart failure].

C Binggeli·R R Wenzel·G Noll

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Abstract

Congestive heart failure is a frequent cardiovascular disease with a poor prognosis in advanced stages. Activation of neurohumoral systems such as the renin-angiotensin system and the sympathetic nervous system as well as impairment of local regulatory mechanisms (i.e. adrenoceptors, endothelial factors) play an important role in the pathogenesis and prognosis of the disease. The increase in peripheral resistance is due to imbalance of vasoconstrictors and vasodilators in favour of the vasoconstrictors and to changes in endothelial function, i.e. impaired production of nitric oxide, increased production of endothelin. Sodium and volume retention as well as the activation of the renin-angiotensin system increase preload. The sympathetic nervous system, which is known to be an independent negative prognostic factor, is activated and interacts with the renin-angiotensin system; however, up to now it is uncertain, whether these pathophysiological findings contribute to the development of congestive heart failure or if they are only secondary phenomena.

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Amino Acid Sequence Animals Endothelins Endothelium, Vascular Heart Failure Humans Molecular Sequence Data Nitric Oxide Renin-Angiotensin System Sympathetic Nervous System Vascular Resistance Vasoconstriction English Abstract Journal Article Review

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C Binggeli, R R Wenzel, G Noll. 1996-02-20. [Sympathetic nervous system and endothelial function in heart failure].. https://pubmed.ncbi.nlm.nih.gov/8701190/

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