Immunosuppressive cyclolignans.

M Gordaliza; G T Faircloth; M A Castro; J M Miguel del Corral; M L López-Vázquez; A San Feliciano

doi:10.1021/jm960023h

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Immunosuppressive cyclolignans.

M Gordaliza·G T Faircloth·M A Castro·J M Miguel del Corral·M L López-Vázquez·A San Feliciano

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Abstract

The immunosuppressive activity of several lactonic, nonlactonic, and heterocycle-fused cyclolignans has been demonstrated for the first time by use of a T-cell-mediated immune response. Of the compounds tested, 4'-demethyldeoxypodophyllotoxin (8), beta-apopicropodophyllin (6), and the isoxazoline-fused cyclolignan 15 are the most potent with respect to their suppression of activated splenocytes.

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Animals Cells, Cultured Immunosuppressive Agents Lignans Lymphocyte Culture Test, Mixed Mice Mice, Inbred BALB C Molecular Structure Spleen Structure-Activity Relationship T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't

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M Gordaliza, G T Faircloth, M A Castro, J M Miguel del Corral, M L López-Vázquez, A San Feliciano. 1996-07-05. Immunosuppressive cyclolignans.. https://doi.org/10.1021/jm960023h

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