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PubMed · 8722178

Cell cycle control of eukaryotic DNA replication.

S E Kearsey·K Labib·D Maiorano
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Abstract

A clearer picture of replication control is emerging through the characterization of proteins, such as cdc18/Cdc6 and members of the mini-chromosome maintenance (MCM) protein family, that are involved in the initiation step. Cyclin B dependent kinases have conserved roles in both Saccharomyces cerevisiae and Schizosaccharomyces pombe, switching on DNA replication in G1 and preventing re-replication in G2. A model is suggested where MCMs and CDKs play complementary roles to ensure 'once-per-cell-cycle' replication, with CDKs maintaining a G1 or G2 state, whereas MCMs provide a cis-acting control on chromatin to prevent reinitiation during a single S phase.

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Cell CycleCell Cycle ProteinsDNA ReplicationYeastsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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S E Kearsey, K Labib, D Maiorano. 1996. Cell cycle control of eukaryotic DNA replication.. https://doi.org/10.1016/s0959-437x(96)80052-9

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