RNA editing: how a message is changed.

R Benne

doi:10.1016/s0959-437x(96)80054-2

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RNA editing: how a message is changed.

R Benne

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Abstract

Considerable progress has been made in unraveling the mechanistic features of RNA editing processes in a number of genetic systems. Recent highlights include the identification of the catalytic subunit of the mammalian apolipoprotein B mRNA editing enzyme as a zinc-dependent cytidine deaminase that binds to RNA, the demonstration that adenosines in brain glutamate receptor pre-mRNAs are converted into inosines and that double-stranded RNA A deaminase (dsRAD), the candidate enzyme, is another zinc-dependent RNA nucleotide deaminase, and a mounting body of evidence for a cleavage-ligation mechanism for U insertion/deletion editing in kinetoplastid protozoa.

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Animals Apolipoproteins B Base Sequence Mitochondria Molecular Sequence Data Nucleoside Deaminases RNA RNA Editing RNA, Mitochondrial Receptors, Glutamate Journal Article Research Support, Non-U.S. Gov't Review

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R Benne. 1996. RNA editing: how a message is changed.. https://doi.org/10.1016/s0959-437x(96)80054-2

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