Normal and pathological mechanisms in retinal vascular development.

R F Gariano; R E Kalina; A E Hendrickson

doi:10.1016/s0039-6257(96)82014-5

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Normal and pathological mechanisms in retinal vascular development.

R F Gariano·R E Kalina·A E Hendrickson

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Abstract

Angiogenesis is a complex biologic process that occurs normally in development and in turnover and remodeling of mature vascular networks. Pathological angiogenesis and neovascularization occur in association with retinal and ocular ischemic diseases, in retinopathy of prematurity and other developmental disorders, and in tumor growth and metastasis. We describe current understanding of cellular and molecular mechanisms of retinal vascular development, highlighting aspects that relate to eye diseases, that provide sites of therapeutic intervention in ophthalmology and that are potential avenues for research.

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Animals Endothelial Growth Factors Fetus Fibroblast Growth Factor 2 Humans Infant, Newborn Neovascularization, Pathologic Neovascularization, Physiologic Nerve Fibers Retinal Vessels Retinopathy of Prematurity Somatomedins Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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R F Gariano, R E Kalina, A E Hendrickson. Normal and pathological mechanisms in retinal vascular development.. https://doi.org/10.1016/s0039-6257(96)82014-5

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