Understanding signal transduction during bacterial infection.

B J Akerley; J F Miller

doi:10.1016/0966-842x(96)10024-x

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Understanding signal transduction during bacterial infection.

B J Akerley·J F Miller

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Abstract

Many known or suspected bacterial virulence factors require environmentally responsive control factors for expression. In Bordetella species, the BvgAS system represses and activates sets of genes, and mediates a biphasic phenotypic transition. Studies using mutants with altered signaling pathways and reversed regulatory connections have provided insights into the role of BvgAS and this phenotypic transition during the Bordetella-host interaction.

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Animals Bacterial Proteins Bordetella Infections Gene Expression Regulation, Bacterial Humans Signal Transduction Transcription Factors Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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B J Akerley, J F Miller. 1996. Understanding signal transduction during bacterial infection.. https://doi.org/10.1016/0966-842x(96)10024-x

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