Behavioral interactions between naloxone and dopamine agonists.

R A Harris; D Snell; H H Loh; E L Way

doi:10.1016/0014-2999(77)90023-1

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Behavioral interactions between naloxone and dopamine agonists.

R A Harris·D Snell·H H Loh·E L Way

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Abstract

A fixed-interval schedule of food presentation was used to study the effects of apomorphine, ET-495 and clonidine and interactions between these drugs and naloxone in the rat. The rate of responding under this schedule was decreased by low doses of apomorphine (0.03--0.3 mg/kg), ET-495 (0.3-1.0 mg/kg) and clonidine (0.03--0.3 mg/kg). Naloxone, at a dose (3 mg/kg) which did not itself alter responding, potentiated the rate decreasing effects of apomorphine and ET-495 but did not alter the effects of clonidine. It is suggested that the rate decreasing effects of low doses of apomorphine and ET-495 may be related to presynaptic inhibition of dopamine neurons and that under certain circumstances naloxone may also inhibit dopaminergic activity.

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Animals Apomorphine Behavior, Animal Clonidine Drug Synergism Instinct Male Naloxone Piperazines Piribedil Rats Receptors, Dopamine Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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R A Harris, D Snell, H H Loh, E L Way. 1977-06-01. Behavioral interactions between naloxone and dopamine agonists.. https://doi.org/10.1016/0014-2999(77)90023-1

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