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Determination of analytical error function for beta-blockers as a possible weighting method for the estimation of the regression parameters.

P Modamio·C F Lastra·E L Mariño
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Abstract

Three analytical methods have been developed and validated for the quantification of beta-blockers (celiprolol, bisoprolol and oxprenolol) using high performance liquid chromatography (HPLC) with UV detection. The methods were determined to be linear, precise and accurate (RSDs were lower than 5%), which allowed the quantitation of beta-blockers assayed at concentrations in the range 25-0.78 micrograms ml-1. After validation of reversed-phase HPLC methods, their analytical error functions were established by a rapid, simple and economical procedure. The discrimination of the best function for each active principle was performed by an appropriate polynomial statistical analysis, yielding SD (microgram ml-1) = 0.0295 + 0.0124C - 3.88 x 10(-4)C2 for celiprolol, 0.0199 + 0.011C - 1.27 x 10(-5)C3 for bisoprolol; and 0.0183 + 0.0089C - 9.68 x 10(-6)C3 for oxprenolol. These analytical error functions are an alternative to the weighting methods used in parameter estimation of beta-blockers.

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Adrenergic beta-AntagonistsBisoprololCeliprololChromatography, High Pressure LiquidOxprenololRegression AnalysisReproducibility of ResultsJournal Article

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P Modamio, C F Lastra, E L Mariño. 1996. Determination of analytical error function for beta-blockers as a possible weighting method for the estimation of the regression parameters.. https://doi.org/10.1016/0731-7085(95)01654-6

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