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PubMed · 873154

Thyroxine-evoked decrease of jejunal lactase activity in adult rats.

P Celano·J Jumawan·O Koldovsky
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Abstract

Daily administration of L-thyroxine (20 micrograms or 200 micrograms/100 g body weight) to adult male rats decreased jejunal lactase activity by 35% after 2-, 3-, 4- and 10 days. Four days of injections of D-thyroxine (200 micrograms/100 g body weight/day) produced a similar decrease of lactase activity. Sucrase activity was uninfluenced except for a 30% increase after daily injections of L-thyroxine (200 micrograms/100 g body weight) for 10 days. Acid beta-galactosidase activity was unaffected by either D- or L-thyroxine.

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AnimalsDose-Response Relationship, DrugGalactosidasesInjections, SubcutaneousIntestine, SmallJejunumMaleRatsSucraseThyroxineJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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P Celano, J Jumawan, O Koldovsky. 1977. Thyroxine-evoked decrease of jejunal lactase activity in adult rats.. https://pubmed.ncbi.nlm.nih.gov/873154/

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