Substance P does not modify mononuclear cell migration into Ehrlich tumor mass.

L V Bonamin; B E Malucelli

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PubMed · 8736130

Substance P does not modify mononuclear cell migration into Ehrlich tumor mass.

L V Bonamin·B E Malucelli

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Abstract

In the present study, seven adult male mice were inoculated with Ehrlich tumor into the footpad after local substance P release was blocked by neurectomy of the sciatic and saphenous nerves. The contralateral footpad was also inoculated but sham-operated, and used as control. This procedure did not modify the percent of CD4+ (about 1-2%), CD8+ (about 1-3%), macrophages (about 21-22%), lymphocyte B (about 0-1%) and NK (about 1-2%) mononuclear cells present among tumor cells. These data suggest that chemotactic activity of substance P may not be relevant in this situation because the lack of this neurotransmitter (checked by immunohistochemistry) secondary to neurectomy did not change the cell migration profile into tumor mass.

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Animals B-Lymphocytes Carcinoma, Ehrlich Tumor Macrophages Male Mice Mice, Inbred Strains Substance P T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't

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L V Bonamin, B E Malucelli. 1996. Substance P does not modify mononuclear cell migration into Ehrlich tumor mass.. https://pubmed.ncbi.nlm.nih.gov/8736130/

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