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PubMed · 8736699

Calcium controls second-messenger signalling in olfactory cilia.

I Boekhoff·C Kroner·H Breer
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Abstract

The increase in intracellular calcium concentration elicited by odorant stimulation seems to be involved in down-regulating the responsiveness of olfactory neurons to subsequent stimuli. The present study suggests that this regulatory effect may be due to a calcium-dependent attenuation of the olfactory signalling cascade; the odor-induced cyclic adenosine monophosphate (cAMP) response in olfactory cilia is diminished by calcium in a dose-dependent manner. This reduced cAMP signal is not due to an activation of phosphodiesterases by elevated calcium levels, but rather seems to be mediated by the inhibition of adenylate cyclase by calcium ions.

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1-Methyl-3-isobutylxanthineAdenylyl CyclasesAnimalsCalciumCiliaColforsinCyclic AMPDose-Response Relationship, DrugNasal SeptumOlfactory PathwaysRatsRats, Sprague-DawleySecond Messenger SystemsSignal TransductionJournal ArticleResearch Support, Non-U.S. Gov't

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I Boekhoff, C Kroner, H Breer. 1996. Calcium controls second-messenger signalling in olfactory cilia.. https://doi.org/10.1016/0898-6568(95)02050-0

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