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PubMed · 8737444

Two-state stochastic models for memory in ion channels.

J Q Fang·T Y Ni·C Z Fu·J Fan·Y Y Guan
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Abstract

AIM: To study quantitatively the memory existing in ion channels. METHODS: Stochastic processes were used to model 2 categories of memory (short-term and long-term) by persisting in the standpoint of two-state, instead of multiple states, but with different transition mechanism. RESULTS: A two-state Markov process with constant transition intensities well fitted the short-term memory and a two-state Markov process within a kind of random environment well fitted the long-term memory. Statistical procedures for parameter estimation were proposed and demonstrated with 2 real examples on the channels of PC12 cells. CONCLUSION: The memory in ion channels can be quantitatively modelled as stochastic process with 2 states.

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Adrenal Gland NeoplasmsHumansIon ChannelsMarkov ChainsMemoryMemory, Short-TermNerve Growth FactorsPheochromocytomaTumor Cells, CulturedJournal ArticleResearch Support, Non-U.S. Gov't

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J Q Fang, T Y Ni, C Z Fu, J Fan, Y Y Guan. 1996. Two-state stochastic models for memory in ion channels.. https://pubmed.ncbi.nlm.nih.gov/8737444/

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