Immunomodulatory function of major histocompatibility complex-derived peptides.

Abstract

Recent advances with regard to the structure and function of the major histocompatibility molecules have given rise to a better understanding of T cell receptor interaction with the major histocompatibility complex plus peptide complex on the surface of antigen-presenting cells, and have highlighted the pivotal role of the peptide in determining the subsequent T cell response. There has therefore been increased interest in the use of synthetic peptides to alter T cell responses to foreign antigens. The purpose of this review is to highlight the recent studies which demonstrate the potential immunomodulatory functions of peptides derived from major histocompatibility complex molecules.