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PubMed · 8739845

Age-related decrease in responsiveness to L-DOPA is not due to changes in dopamine receptor mRNAs or G protein mRNAs.

M Murata·Y Aihara·H Yamanouchi·S Yamada·I Kanazawa
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Abstract

To clarify the cause of the age-related decrease in the responsiveness to L-DOPA seen in parkinsonian patients, we studied age-related changes in the mRNA levels of dopamine receptors (D1, D2) and of G proteins (Gs, Gi, Go) in 22 control human brains aged 50-105 years. Neither the mRNA levels of dopamine receptors or of the G proteins changed with age. Another factor in the receptor-G protein cascade, such as guanine nucleotide binding, may cause the age-related decrease in responsiveness.

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ActinsAgedAged, 80 and overAgingAntiparkinson AgentsBlotting, NorthernBrain ChemistryFemaleGTP-Binding ProteinsHumansIn Vitro TechniquesLevodopaMaleMiddle AgedRNA, MessengerReceptors, DopamineReceptors, Dopamine D1Receptors, Dopamine D2Journal ArticleResearch Support, Non-U.S. Gov't

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M Murata, Y Aihara, H Yamanouchi, S Yamada, I Kanazawa. 1996. Age-related decrease in responsiveness to L-DOPA is not due to changes in dopamine receptor mRNAs or G protein mRNAs.. https://doi.org/10.1007/bf01271245

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