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PubMed · 8741663

[Programmed thymic T cell death and negative selection via Fas and TCR/CD3 complex].

S Kishi
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Abstract

In the immune system of thymic microenvironment, immature T cells are selected by T cell receptor (TCR)-mediated antigen stimulation and most of thymic T cells die by apoptosis. Molecular mechanism for the elimination of autoreactive T cells by apoptotic cell death in thymus is almost unknown, though a differential avidity model for TCR-mediated selection is recently proposed. On the other hand, Fas antigen (Fas), which is apoptosis inducing cell surface receptor, is expressed on antigen stimulated human thymocytes and involved in superantigen-induced negative selection. Recent studies have suggested that CD30 and CD40 ligand (gp39) on thymocytes is also involved in a part of negative selection. Thus, it is likely that the process of negative selection may involve multiple, and to some extent redundant, costimulation signals.

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ApoptosisHumansReceptor-CD3 Complex, Antigen, T-CellSignal TransductionT-LymphocytesThymus Glandfas ReceptorJournal ArticleReview

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BibTeXRIS

S Kishi. 1996. [Programmed thymic T cell death and negative selection via Fas and TCR/CD3 complex].. https://pubmed.ncbi.nlm.nih.gov/8741663/

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