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PubMed · 8744656

Continuous versus split-course irradiation for lung cancer. Immunological implications.

L Vucković-Dekić·N Stanojević-Bakić·M Dekić·O Frim
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Abstract

The therapeutical irradiation for lung cancer causes profound disturbances of host's general immunocompetence, the cellular immunodepression being the dominant finding. It is thought that split-course technique holds certain advantage over the continuous irradiation, since the former includes an interruption of 4 week duration, thus allowing the lymphopoietic system to recover to a certain degree. In this report, we compared the radiotherapy-due alterations of several parameters of cellular immunity (the number and function of total T cells, active T cells and the cells of monocyte/macrophage lineage), immediately after the completion of therapy in either continuously (n = 13) or split-course-irradiated (n = 12) lung cancer patients. All patients had received the total dose of 60 Gy. Both therapeutical techniques caused alterations of the parameters tested: the significant decrease of the total and active T cells and their proliferative responses, while the phagocytic activity and the number of mononuclear phagocytes were increased, the latter being affected to a lesser extent in split-course-treated patients. Our results suggest that both techniques have similar immunodepressant effect on the cellular immunity of lung cancer patients.

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AdultAgedHumansImmune ToleranceLung NeoplasmsMiddle AgedRadiotherapyComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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L Vucković-Dekić, N Stanojević-Bakić, M Dekić, O Frim. 1995. Continuous versus split-course irradiation for lung cancer. Immunological implications.. https://pubmed.ncbi.nlm.nih.gov/8744656/

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