Immunoadhesins: principles and applications.

S M Chamow; A Ashkenazi

doi:10.1016/0167-7799(96)80921-8

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Immunoadhesins: principles and applications.

S M Chamow·A Ashkenazi

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Abstract

The prototypic immunoadhesin is an antibody-like molecule that fuses the Fc region of an immunoglobulin and the ligand-binding region of a receptor or adhesion molecule. In this article, we review some important structural and functional principles of immunoadhesins. In addition, we highlight some unique advantages of immunoadhesins as experimental tools in biology, as well as some of their exciting potential applications in medicine.

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Animals Biotechnology Cell Adhesion Molecules Humans Immunoglobulin Fc Fragments Ligands Models, Structural Molecular Sequence Data Receptors, Cell Surface Receptors, Immunologic Recombinant Proteins Journal Article Review

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S M Chamow, A Ashkenazi. 1996. Immunoadhesins: principles and applications.. https://doi.org/10.1016/0167-7799(96)80921-8

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