Carmofur-induced leukoencephalopathy: MRI.

S Matsumoto; S Nishizawa; M Murakami; S Noma; A Sano; Y Kuroda

doi:10.1007/bf00593382

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Carmofur-induced leukoencephalopathy: MRI.

S Matsumoto·S Nishizawa·M Murakami·S Noma·A Sano·Y Kuroda

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Abstract

Carmofur, a derivative of 5-fluorouracil, has recently been noted to have an infrequent but serious association with leukoencephalopathy. To our knowledge, there has been no report of early MRI findings in this leukoencephalopathy. We describe a case in which diffuse high signal intensity of the entire cerebral white matter, including the corpus callosum, was seen on T2-weighted magnetic resonance images. Although similar findings can be seen in many other diseases, carmofur-induced leukoencephalopathy should be suspected in a patient treated with carmofur. It is important to know the clinical and MRI characteristics of this condition, for early diagnosis and better prognosis.

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S Matsumoto, S Nishizawa, M Murakami, S Noma, A Sano, Y Kuroda. 1995. Carmofur-induced leukoencephalopathy: MRI.. https://doi.org/10.1007/bf00593382

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