Isoxazole anthelmintics.

J B Carr; H G Durham; D K Hass

doi:10.1021/jm00217a014

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Isoxazole anthelmintics.

J B Carr·H G Durham·D K Hass

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Abstract

A series of 3-halo-5-phenyl- and 3-phenyl-5-haloisoxazoles has demonstrated anthelmintic activity at doses ranging from 16 to 500 mg/kg orally against the rat roundworm, Nippostrongylus braziliensis. In the 5-phenyl series a halogen at the 3 position of the isoxazole ring was required for activity. However, in the 3-phenyl series activity was maintained after replacement of the 5-halogen with certain alkoxyl, thioalkoxyl, or amino groups. The 3-phenyl and 5-phenyl series apparently are not acting biologically at a common receptor site. Synthetic methods and structure-activity relationships are discussed.

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Animals Anthelmintics Hookworm Infections Isoxazoles Nippostrongylus Oxazoles Rats Structure-Activity Relationship Journal Article

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J B Carr, H G Durham, D K Hass. 1977. Isoxazole anthelmintics.. https://doi.org/10.1021/jm00217a014

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