PubMed HealthSearch

PubMed · 8750103

Microcomputer-based pulse stimulator.

Abstract

A low-cost PC-based 2-channel stimulator was designed. This device can generate regular current pulses for many neuroscience experiments. It can also generate irregular pulses for nerve stimulation, thus could possibly avoid the problem of sensitization or habituation in the central nervous system. The stimulation frequency (can be < 0.0005 Hz) and pulse duration (5 microseconds to 65 ms) of this device can be programmed by an interactive user interface. Furthermore, the output current (0-10 mA) can be continuously varied and was optically isolated to minimize stimulus artifact. Moreover, features such as low-power consumption (0.2 mA of a 9 V battery) and high-compliance output (> 120 V) could accommodate the stimulator for widespread applications. A trial of nerve stimulation was illustrated besides the electrical specifications of the stimulator.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

F S Jaw, S J Liu, T S Kuo, C Y Wang. 1995. Microcomputer-based pulse stimulator.. https://doi.org/10.1016/0165-0270(95)00076-3

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Spatiotemporal evolution of ventricular fibrillation.

Sudden cardiac death is the leading cause of death in the industrialized world, with the majority of such tragedies being due to ventricular fibrillation. Ventricular fibrillation is a frenzied and irregular disturbance of the heart rhythm that quickly renders the heart incapable of sustaining life. Rotors, electrophysiological structures that emit rotating spiral waves, occur in several systems that all share with the heart the functional properties of excitability and refractoriness. These re-entrant waves, seen in numerical solutions of simplified models of cardiac tissue, may occur during ventricular tachycardias. It has been difficult to detect such forms of re-entry in fibrillating mammalian ventricles. Here we show that, in isolated perfused dog hearts, high spatial and temporal resolution mapping of optical transmembrane potentials can easily detect transiently erupting rotors during the early phase of ventricular fibrillation. This activity is characterized by a relatively high spatiotemporal cross-correlation. During this early fibrillatory interval, frequent wavefront collisions and wavebreak generation are also dominant features. Interestingly, this spatiotemporal pattern undergoes an evolution to a less highly spatially correlated mechanism that lacks the epicardial manifestations of rotors despite continued myocardial perfusion.

Electric Stimulation