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PubMed · 8757221

CD45 isoforms on human CD4+ T-cell subsets.

M C Shanafelt·H Yssel·C Soderberg·L Steinman·D C Adelman·G Peltz·R Lahesmaa
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Abstract

We have examined the level of surface expression and functional properties of leukocyte function associated antigen-1, very late antigen-4, and CD45 isoforms on a panel of human CD4+ T-cell clones representative of TH0, TH1, and TH2 cells. There were no qualitative differences in the expression of these antigens among the three types of CD4+ T-cell clones. However, CD45RB was the only CD45 isoform that provided a costimulatory signal in a solid-phase antibody-induced cellular proliferation assay. Additionally, the antigen-induced proliferative response of T-cell clones was inhibited by soluble anti-CD45RO and anti-CD45RB antibodies. Our results suggest that CD45 isoforms differentially provide costimulatory signals to T cells. However, the ability of each CD45 isoform to provide a costimulatory signal does not differ among the TH0, TH1, or TH2 T-cell populations.

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CD4-Positive T-LymphocytesCell MovementClone CellsHumansLeukocyte Common AntigensLymphocyte ActivationTh1 CellsTh2 CellsJournal ArticleResearch Support, Non-U.S. Gov't

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M C Shanafelt, H Yssel, C Soderberg, L Steinman, D C Adelman, G Peltz, R Lahesmaa. 1996. CD45 isoforms on human CD4+ T-cell subsets.. https://doi.org/10.1016/s0091-6749(96)70168-9

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