[Oral testing for sulfite asthma].

H Hein; D Kirsten; R A Jörres; H Magnussen

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PubMed · 8766371

[Oral testing for sulfite asthma].

H Hein·D Kirsten·R A Jörres·H Magnussen

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Abstract

AIM OF THE STUDY: Patients with asthma may develop bronchoconstriction after ingestion of sulfites. We studied the sensitivity and specificity of an oral provocation challenge with metabisulfite to detect a sulfite-sensitive asthma. METHODS: We performed an oral dose-response metabisulfite challenge in 44 patients with a history of sulfite-sensitive asthma, 27 patients with asthma but without a history of sulfite sensitivity, and 8 control subjects without asthma. Metabisulfite was administered in capsules in a single-blind manner. Airway response was assessed by FEV decline, measured 30' after each dose. RESULTS: Thirty-nine percent of patients with a history of sulfite-sensitive asthma demonstrated a significant bronchoconstriction after ingestion of metabisulfite, whereas patients without an appropriate history and control subjects did not respond to the challenge. CONCLUSIONS: The oral metabisulfite challenge exhibits a high specificity (100%) but low sensitivity of about 40%. Nonetheless, taking into account the uncertainties in the patients' history of sulfite-sensitive asthma, the oral metabisulfite challenge as performed by us is a useful method for the diagnosis of sulfite sensitive asthma.

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Administration, Oral Adult Airway Resistance Asthma Female Forced Expiratory Volume Humans Male Middle Aged Respiratory Hypersensitivity Single-Blind Method Sulfites Vital Capacity English Abstract Journal Article

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H Hein, D Kirsten, R A Jörres, H Magnussen. 1996. [Oral testing for sulfite asthma].. https://pubmed.ncbi.nlm.nih.gov/8766371/

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