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PubMed · 8768146

[Biochemical changes in fibromyalgia].

W Samborski·T Stratz·T Schochat·P Mennet·W Müller
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Abstract

Different changes in neurotransmitters were observed in patients with fibromyalgia. The aim of the study was to confirm the diagnosis fibromyalgia by determination of several of these substances. In 60 patients, who met the ACR classification criteria for fibromyalgia and in 20 sex and age matched controls the following estimations were made: serotonin (EIA), somatomedin C (RIA), calcitonin (RIA), prostaglandin E2 (EIA), oxytocin (RIA), ACTH (RIA), substance P (EIA), TSH (LIA), prolactin (LIA). In comparison to healthy controls, patients with fibromyalgia revealed significantly decreased levels of serotonin, somatomedin C, calcitonin, prostaglandin E2 and a significantly increased level of prolactin. No significant differences were found in the levels of ACTH, substance P and TSH. These results suggest that the diagnosis of fibromyalgia can be confirmed by various biochemical parameters, but further investigations must be carried out to value the diagnostic relevance of these findings.

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Adrenocorticotropic HormoneAdultAgedDinoprostoneFemaleFibromyalgiaHormonesHumansInsulin-Like Growth Factor IMaleMiddle AgedNeurologic ExaminationNeurotransmitter AgentsOxytocinProlactinSerotoninSubstance PThyrotropinEnglish AbstractJournal Article

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W Samborski, T Stratz, T Schochat, P Mennet, W Müller. [Biochemical changes in fibromyalgia].. https://pubmed.ncbi.nlm.nih.gov/8768146/

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