Proteasome: from structure to function.

D Stock; P M Nederlof; E Seemüller; W Baumeister; R Huber; J Löwe

doi:10.1016/s0958-1669(96)80111-x

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Proteasome: from structure to function.

D Stock·P M Nederlof·E Seemüller·W Baumeister·R Huber·J Löwe

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Abstract

During the past two years, significant progress has been made in understanding the structure and function of the proteasome. Recent work has revealed the three-dimensional structure of the 700 kDa proteolytic complex at atomic resolution and elucidated its novel catalytic mechanism. Close relationships to a number of other amino-terminal hydrolases have emerged, making the proteasomal subunits the prototype of this newly discovered structural superfamily.

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Animals Cysteine Endopeptidases Humans Models, Biological Models, Immunological Models, Molecular Multienzyme Complexes Proteasome Endopeptidase Complex Protein Conformation Protein Folding Journal Article Review

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D Stock, P M Nederlof, E Seemüller, W Baumeister, R Huber, J Löwe. 1996. Proteasome: from structure to function.. https://doi.org/10.1016/s0958-1669(96)80111-x

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