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PubMed · 8770739

Does peri-operative guanethidine prevent reflex sympathetic dystrophy?

C Gschwind·R Fricker·G Lacher·M Jung
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Abstract

The use of intravenous guanethidine blocks is an accepted treatment for established reflex sympathetic dystrophy (RSD). Some units administer intravenous guanethidine peri-operatively with the intention of protecting their patients from post-operative dystrophy. There have been no studies confirming this protective effect of peri-operative guanethidine. Between 1992 and 1994 we performed a prospective randomized double blind study in 71 patients undergoing fasciectomy for Duputyren's disease. Peri-operative guanethidine did not prevent post-operative RSD in our series.

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Analysis of VarianceDouble-Blind MethodDrug Administration ScheduleDupuytren ContractureFasciotomyGuanethidineHumansInjections, IntravenousPostoperative ComplicationsProspective StudiesReflex Sympathetic DystrophyRisk FactorsSympatholyticsTreatment OutcomeClinical TrialJournal ArticleRandomized Controlled Trial

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C Gschwind, R Fricker, G Lacher, M Jung. 1995. Does peri-operative guanethidine prevent reflex sympathetic dystrophy?. https://doi.org/10.1016/s0266-7681(95)80045-x

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