Levodopa stability in solution: time course, environmental effects, and practical recommendations for clinical use.

E J Pappert; C Buhrfiend; J W Lipton; P M Carvey; G T Stebbins; C G Goetz

doi:10.1002/mds.870110106

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Levodopa stability in solution: time course, environmental effects, and practical recommendations for clinical use.

E J Pappert·C Buhrfiend·J W Lipton·P M Carvey·G T Stebbins·C G Goetz

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Abstract

We defined the temporal stability characteristics of levodopa/carbidopa (LD/CD) solution, and determined the effects of temperature, ascorbate, and light on LD stability over 7 days. At room temperature and without ascorbate, LD levels significantly declined by 48 h. Ascorbate prolonged stability to 72 h. Refrigeration and freezing prevented a significant decline in LD levels for the full 7 days. Light or darkness had no effect on stability. LD/CD solution, if made daily, requires no special handling and longer stability is maintained with ascorbate, refrigeration, or freezing.

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Antiparkinson Agents Ascorbic Acid Carbidopa Drug Combinations Drug Stability Drug Storage Humans Levodopa Light Parkinson Disease Temperature Time Factors Journal Article

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E J Pappert, C Buhrfiend, J W Lipton, P M Carvey, G T Stebbins, C G Goetz. 1996. Levodopa stability in solution: time course, environmental effects, and practical recommendations for clinical use.. https://doi.org/10.1002/mds.870110106

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