PubMed · 8777813
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J M Mato. 1996. Bridging basic science and clinical research.. https://doi.org/10.1042/cs0900147a
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A World-Wide Web service has been constructed to assist the development of force field parameters extending the AMBER force fields. This service extracts parameters from the standard AMBER force field parameter databases. From a Web-based interface the user can choose between bond, angle and torsional parameters with certain constraints on element and/or atom hybridization. The software constructed for the purpose of finding appropriate parameters will locate standard AMBER force field parameters matching the user specification. For bond and angle parameters a scatter plot of the reference values against force constants is provided. This service has been produced to assist in extraction and evaluation of parameters that may be useful for molecules other than proteins and nucleic acids.
An artificial life entertainment software product called Creatures was released in Europe in late 1996 and in the United States and Japan in mid-1997. When installed on a domestic computer (PC or Macintosh), each Creatures CD-ROM creates a virtual world in which autonomous software agents exist. The agents, known as "norn," interact with the human user, with each other, and with objects in their virtual world. Each norn coordinates perception and action via its own modular recurrent neural network. Each network has Hebbian learning, plus diffuse modulation of activity via a "hormonal" system that is part of that norns "biochemistry." Details of each norns neural network and biochemistry are genetically specified, and norns can breed via sexual reproduction. In the reproduction process, genetic material may be mutated and may also be subjected to "gene duplications" that enable potentially unlimited increases in complexity of the norns' design. Over 500,000 Creatures CD-ROMS have now been sold. As each installed copy of Creatures can support 5 to 10 simultaneously existing individual norns, it seems reasonable to estimate that there are up to 5 million norns existing in the "cyberspace" provided by the global Creatures user community. Continued growth of the global norn population, to figures measured in tens of millions, is quite likely. Although a commercial product, the Creatures digital ecosystem should be of interest to artificial life scientists. There are obvious parallels with Yaeger's PolyWorld and Ray's NetTierra systems. This article provides a detailed discussion of the links between the artificial life literature and the technology used in Creatures and includes anecdotal discussion of the "digital naturalism" witnessed on the many independent websites maintained by Creatures enthusiasts.
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