PubMed HealthSearch

PubMed · 8785885

Topical corticosteroids.

Abstract

Topical corticosteroids represent a frequently prescribed form of treatment for plaque-type psoriasis vulgaris. Topical corticosteroids have immunosuppressive, antimitotic, and anti-inflammatory actions that can contribute to the temporary alleviation of psoriasis. Protracted topical steroid-induced remissions are possible if psoriasis plaques can be cleared or almost cleared and then treated in an intermittent fashion, thereby limiting exposure and reducing the possibility of adverse experiences.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

H I Katz. 1995. Topical corticosteroids.. https://pubmed.ncbi.nlm.nih.gov/8785885/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Re-epithelialization of the rat cornea is accelerated by blockade of opioid receptors.

A native opioid peptide, [Met5]-enkephalin, termed opioid growth factor (OGF), serves as a constitutively expressed and autocrine produced inhibitory molecule related to developing, neoplastic, renewing, and healing tissues. The present study was designed to examine the effects of interfering with opioid-receptor interaction during re-epithelialization of the cornea in the rat using both systemic injections and topical applications of the potent opioid antagonist naltrexone (NTX). A 4 mm diameter epithelial defect was made in the center of the rat cornea. NTX injected twice daily or applied as eyedrops four times daily significantly accelerated re-epithelialization compared to controls. Beginning as early as 8 h after wounding, both the systemic and topical NTX treatment groups had defects that were approximately 10% to 67% smaller than control abrasions at the time points examined. Similarly, the rate of healing for the NTX groups was 4.7- and 2.8-fold greater than controls for systemic and topical paradigms, respectively. The incidence of complete re-epithelialization in animals given systemic administration of NTX was markedly accelerated in comparison to control rats; however, differences in incidence of repair between NTX and control groups receiving topical application were not observed. These results show that native opioid peptides function in wound healing, and exert a tonically inhibitory influence at the receptor level on repair of corneal epithelial injuries.

Administration, Topical

Heteromeric gap junction channels in rat hepatocytes in which the expression of connexin26 is induced.

More than one isotype of the gap junction channel-forming protein subunit, known as connexin, are synthesized in most mammalian cells. Using a modified primary cell culture of rat hepatocytes, in which both connexin32 and connexin26 were expressed in a comparable degree, the molecular composition of connexin subtypes in a gap junction channel (i.e., homomeric or heteromeric) was studied. A fluorescent dye Lucifer Yellow-coupling among hepatocytes was blocked in the presence of 20 microM beta-glycyrrhetinic acid, and antagonist for the gap junction channel. Similarly, either one of the antibodies raised against connexin32 or connexin26 completely inhibited dye-coupling activity among hepatocytes. In addition, we studied the dye-coupling properties at different extracellular pHs in two primary rat hepatocytes: one in which connexin26 was induced, and the other which expresses connexin32 as a major gap junction channel protein. The dye-coupling among the connexin26-induced hepatocytes was more sensitive to lowering pHs than among the normal hepatocytes, in which less than 5% of gap junction protein is connexin26. Taken together, data obtained in our study strongly suggest that the connexins (32 & 26) are assembled to form heteromeric, rather than homomeric, gap junction channels in the connexin226-induced rat hepatocytes.

Administration, Topical