T cells commit suicide, but B cells are murdered!

D W Scott; T Grdina; Y Shi

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PubMed · 8786289

T cells commit suicide, but B cells are murdered!

D W Scott·T Grdina·Y Shi

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Abstract

In addition to self tolerance, the immune system needs to be regulated when a response has been initiated. Recent data suggest that activated T and B cells, as well as immature lymphocytes, are susceptible to programmed cell death and that Fas:Fas ligand (FasL) interactions play an important role in this process. However, while T cells may kill themselves via a Fas-dependent pathway, we propose that B cells undergo activation-induced apoptosis independent of Fas, yet can be susceptible to T cell-mediated, FasL-induced death. Therefore, T cells can "commit suicide," but B cells are "murdered" during the regulation of an immune response! Further evidence is presented to support the hypothesis that T cell and B cell apoptosis, are initiated through fundamentally different pathways.

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Animals Apoptosis B-Lymphocytes CD40 Antigens CD40 Ligand Fas Ligand Protein Humans Ligands Membrane Glycoproteins Models, Biological T-Lymphocytes fas Receptor Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.Review

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D W Scott, T Grdina, Y Shi. 1996-04-01. T cells commit suicide, but B cells are murdered!. https://pubmed.ncbi.nlm.nih.gov/8786289/

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