Genetic differences in nicotine-induced conditioned taste aversion.

F O Risinger; M M Brown

doi:10.1016/0024-3205(96)00051-3

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Genetic differences in nicotine-induced conditioned taste aversion.

F O Risinger·M M Brown

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Abstract

Genetic differences in nicotine-induced conditioned taste aversion were examined using inbred mice. Adult male C57BL/6J, DBA/2J, BALB/cJ and C3H/heJ mice were adapted to a 2-h per day water access regimen. Subsequently, mice received nicotine injections (0.5, 1.0 or 2.0 mg/kg) immediately after 1-h access to a NaCl flavored solution. DBA and C3H mice developed dose-dependent aversions to the nicotine-paired flavor. BALB mice showed only minor reductions in intake with no difference between the nicotine dose groups. C57BL mice did not show development of nicotine-induced conditioned taste aversion. These results demonstrate that nicotine's aversion motivational effect is strongly influenced by genotype. Further, genetic sensitivity (DBA mice) or insensitivity (C57BL mice) to nicotine-induced conditioned taste aversion was similar to reports of genetic sensitivity to ethanol's aversive effect measured in this design.

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Animals Avoidance Learning Conditioning, Psychological Dose-Response Relationship, Drug Male Mice Mice, Inbred C57BL Nicotine Taste Journal Article Research Support, U.S. Gov't, P.H.S.

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F O Risinger, M M Brown. 1996. Genetic differences in nicotine-induced conditioned taste aversion.. https://doi.org/10.1016/0024-3205(96)00051-3

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