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A brute force dichotomization approach to quantitative trait linkage analysis.

J N Bailey·L Almasy
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Abstract

The effect of dichotomizing a continuous phenotype in linkage analysis of a simulated oligogenic trait is explored. We conclude that dichotomization does not in itself preclude the detection of loci which account for as little as 16% of the genetic variance of the disease. The effects of inclusion of known covariates and quantitative trait linkage analysis are also discussed.

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Genetic Diseases, InbornGenetic LinkageHumansLod ScorePhenotypePredictive Value of TestsSoftwareJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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J N Bailey, L Almasy. 1995. A brute force dichotomization approach to quantitative trait linkage analysis.. https://doi.org/10.1002/gepi.1370120631

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