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PubMed · 87897

Resorption of bone.

J F Loutit·N W Nisbet
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Abstract

The cell-system responsible for resorption of bone is now considered to be a derivative of haematopoietic bone-marrow, not skeletal connective tissue. Consideration of mutant mice and rats, with defects of bone resorption giving osteopetrosis, suggests that the primary defect is of the professional scavengers, the mononuclear-phagocyte system, failing to recognise effete bone. To explain associated defects of thymic lymphocytes it is postulated that the mononuclear-phagocyte system may be activated to a major or minor extent by professional recognisers, thymic lymphocytes, as happens in some inflammatory reactions.

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AnimalsBone ResorptionGenes, RecessiveHumansMiceMutationOsteoblastsOsteoclastsOsteopetrosisPhagocytosisRatsT-LymphocytesJournal Article

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J F Loutit, N W Nisbet. 1979-07-07. Resorption of bone.. https://doi.org/10.1016/s0140-6736(79)90186-7

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